{"id":45,"date":"2026-06-13T10:11:03","date_gmt":"2026-06-13T08:11:03","guid":{"rendered":"https:\/\/internationalsciencereview.com\/zh-tw\/2026\/06\/13\/%e8%86%bd%e6%b1%81%e9%85%b8%e5%9c%a8%e9%98%bf%e7%88%be%e8%8c%a8%e6%b5%b7%e9%bb%98%e7%97%85%e4%b8%ad%e6%89%ae%e6%bc%94%e9%97%9c%e9%8d%b5%e8%a7%92%e8%89%b2\/"},"modified":"2026-06-13T10:12:37","modified_gmt":"2026-06-13T08:12:37","slug":"%e8%86%bd%e6%b1%81%e9%85%b8%e5%9c%a8%e9%98%bf%e7%88%be%e8%8c%a8%e6%b5%b7%e9%bb%98%e7%97%85%e4%b8%ad%e6%89%ae%e6%bc%94%e9%97%9c%e9%8d%b5%e8%a7%92%e8%89%b2","status":"publish","type":"post","link":"https:\/\/internationalsciencereview.com\/zh-tw\/2026\/06\/13\/%e8%86%bd%e6%b1%81%e9%85%b8%e5%9c%a8%e9%98%bf%e7%88%be%e8%8c%a8%e6%b5%b7%e9%bb%98%e7%97%85%e4%b8%ad%e6%89%ae%e6%bc%94%e9%97%9c%e9%8d%b5%e8%a7%92%e8%89%b2\/","title":{"rendered":"\u81bd\u6c41\u9178\u5728\u963f\u723e\u8328\u6d77\u9ed8\u75c5\u4e2d\u626e\u6f14\u95dc\u9375\u89d2\u8272"},"content":{"rendered":"

\u81bd\u6c41\u9178\u5728\u963f\u723e\u8328\u6d77\u9ed8\u75c5\u4e2d\u626e\u6f14\u95dc\u9375\u89d2\u8272<\/h1>\n

\u81bd\u6c41\u9178\u9577\u671f\u4ee5\u4f86\u56e0\u5176\u5728\u8102\u80aa\u6d88\u5316\u548c\u809d\u81df\u4ee3\u8b1d\u4e2d\u7684\u4f5c\u7528\u800c\u70ba\u4eba\u6240\u77e5\uff0c\u4f46\u5b83\u5011\u4e5f\u5f71\u97ff\u8457\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u3002\u5b83\u5011\u4f5c\u70ba\u4fe1\u865f\u5206\u5b50\uff0c\u80fd\u5920\u901a\u904e\u809d-\u8178-\u8166\u8ef8\u8abf\u7bc0\u5927\u8166\u7684\u7a69\u614b\u3002\u9019\u4e9b\u7531\u809d\u81df\u5f9e\u81bd\u56fa\u9187\u5408\u6210\u7684\u5316\u5408\u7269\uff0c\u7d93\u8178\u9053\u7d30\u83cc\u8f49\u5316\u70ba\u6b21\u7d1a\u81bd\u6c41\u9178\uff0c\u7136\u5f8c\u5927\u90e8\u5206\u88ab\u6a5f\u9ad4\u56de\u6536\u5229\u7528\u3002\u5176\u4e2d\u4e00\u5c0f\u90e8\u5206\u751a\u81f3\u80fd\u5230\u9054\u5927\u8166\uff0c\u4e26\u6839\u64da\u5176\u89aa\u6c34\u6216\u89aa\u8102\u6027\u8cea\u7a7f\u8d8a\u8840\u8166\u5c4f\u969c\u3002<\/p>\n

\u5728\u963f\u723e\u8328\u6d77\u9ed8\u75c5\u4e2d\uff0c\u4ee5\u03b2-\u6dc0\u7c89\u6a23\u80bd\u548c\u7570\u5e38tau\u86cb\u767d\u7a4d\u805a\u70ba\u7279\u5fb5\uff0c\u81bd\u6c41\u9178\u7684\u5206\u5e03\u5f80\u5f80\u51fa\u73fe\u7d0a\u4e82\u3002\u7814\u7a76\u986f\u793a\uff0c\u521d\u7d1a\u81bd\u6c41\u9178\u6e1b\u5c11\uff0c\u800c\u6b21\u7d1a\u81bd\u6c41\u9178\uff08\u5c24\u5176\u662f\u89aa\u8102\u6027\u7684\u53bb\u6c27\u81bd\u9178\u548c\u77f3\u81bd\u9178\uff09\u589e\u52a0\u3002\u9019\u4e9b\u6b21\u7d1a\u81bd\u6c41\u9178\u904e\u91cf\u6642\uff0c\u6703\u4fc3\u9032\u8840\u8166\u5c4f\u969c\u7834\u88c2\u548c\u795e\u7d93\u6bd2\u6027\uff0c\u5f9e\u800c\u52a0\u91cd\u75be\u75c5\u75c7\u72c0\u3002\u76f8\u53cd\uff0c\u67d0\u4e9b\u89aa\u6c34\u6027\u81bd\u6c41\u9178\uff08\u5982\u725b\u78fa\u53bb\u6c27\u81bd\u9178\uff09\u5177\u6709\u4fdd\u8b77\u4f5c\u7528\uff0c\u80fd\u5920\u6e1b\u5c11\u708e\u75c7\u4e26\u9650\u5236\u6dc0\u7c89\u6a23\u6591\u584a\u7684\u5f62\u6210\u3002<\/p>\n

\u9019\u4e9b\u5206\u5b50\u901a\u904e\u6fc0\u6d3b\u5927\u8166\u4e2d\u7684\u7279\u5b9a\u53d7\u9ad4\uff08\u5982FXR\u548cTGR5\uff09\u76f4\u63a5\u4f5c\u7528\u65bc\u5927\u8166\uff0c\u9019\u4e9b\u53d7\u9ad4\u8abf\u7bc0\u795e\u7d93\u905e\u8cea\u6d3b\u6027\u548c\u795e\u7d93\u884c\u70ba\u53cd\u61c9\u3002\u4f8b\u5982\uff0cFXR\u6291\u5236\u4fc3\u708e\u7d30\u80de\u56e0\u5b50\u7684\u7522\u751f\uff0c\u800cTGR5\u5247\u9650\u5236\u5c0f\u81a0\u8cea\u7d30\u80de\u7684\u6fc0\u6d3b\uff0c\u5f9e\u800c\u6e1b\u5c11\u795e\u7d93\u708e\u75c7\u3002\u6b64\u5916\uff0c\u81bd\u6c41\u9178\u9084\u523a\u6fc0\u8178\u9053\u6fc0\u7d20\uff08\u5982GLP-1\u548cFGF19\uff09\u7684\u91cb\u653e\uff0c\u9019\u4e9b\u6fc0\u7d20\u80fd\u6539\u5584\u5927\u8166\u5c0d\u80f0\u5cf6\u7d20\u7684\u654f\u611f\u6027\uff0c\u4e26\u652f\u6301\u8a8d\u77e5\u529f\u80fd\u3002\u5176\u4e2d\uff0cGLP-1\u7279\u5225\u80fd\u589e\u5f37\u795e\u7d93\u71df\u990a\u56e0\u5b50\u7684\u7522\u751f\uff0c\u4fdd\u8b77\u795e\u7d93\u5143\u514d\u53d7\u9000\u5316\u3002<\/p>\n

\u540c\u6642\uff0c\u81bd\u6c41\u9178\u9084\u5f71\u97ff\u8178\u9053\u5fae\u751f\u7269\u7fa4\u7684\u7d44\u6210\u3002\u67d0\u4e9b\u7d30\u83cc\uff08\u5982\u68ad\u83cc\u5c6c<\/em>\uff09\u5c07\u521d\u7d1a\u81bd\u6c41\u9178\u8f49\u5316\u70ba\u53ef\u80fd\u5177\u6709\u795e\u7d93\u6bd2\u6027\u7684\u6b21\u7d1a\u81bd\u6c41\u9178\u3002\u9019\u7a2e\u83cc\u7fa4\u5931\u8861\uff08\u7a31\u70ba\u83cc\u7fa4\u5931\u8abf\uff09\u53ef\u80fd\u901a\u904e\u4fc3\u9032\u6709\u5bb3\u4ee3\u8b1d\u7269\u7684\u7a4d\u805a\uff0c\u52a0\u5287\u963f\u723e\u8328\u6d77\u9ed8\u75c5\u7684\u75c5\u7406\u6a5f\u5236\u3002\u8ff7\u8d70\u795e\u7d93\u4f5c\u70ba\u9023\u63a5\u8178\u9053\u548c\u5927\u8166\u7684\u901a\u9053\uff0c\u4e5f\u5728\u50b3\u905e\u9019\u4e9b\u4ee3\u8b1d\u7269\u7684\u4fe1\u865f\u4e2d\u626e\u6f14\u95dc\u9375\u89d2\u8272\uff0c\u6709\u52a9\u65bc\u8abf\u7bc0\u708e\u75c7\u548c\u8a8d\u77e5\u529f\u80fd\u3002<\/p>\n

\u6700\u5f8c\uff0c\u89aa\u6c34\u6027\u81bd\u6c41\u9178\uff08\u5982\u718a\u53bb\u6c27\u81bd\u9178\uff09\u5728\u81e8\u5e8a\u524d\u6a21\u578b\u4e2d\u8868\u73fe\u51fa\u795e\u7d93\u4fdd\u8b77\u7279\u6027\uff0c\u80fd\u6e1b\u8f15\u8166\u640d\u50b7\u4e26\u4fdd\u8b77\u8a18\u61b6\u529f\u80fd\u3002\u5118\u7ba1\u5176\u6cbb\u7642\u6f5b\u529b\u4ee4\u4eba\u671f\u5f85\uff0c\u4f46\u4ecd\u9700\u66f4\u6df1\u5165\u7684\u81e8\u5e8a\u8a66\u9a57\u4f86\u78ba\u8a8d\u5176\u5728\u4eba\u985e\u8eab\u4e0a\u7684\u6709\u6548\u6027\u3002\u56e0\u6b64\uff0c\u81bd\u6c41\u9178\u70ba\u7406\u89e3\u548c\u6cbb\u7642\u963f\u723e\u8328\u6d77\u9ed8\u75c5\u63d0\u4f9b\u4e86\u4e00\u689d\u5275\u65b0\u9014\u5f91\uff0c\u540c\u6642\u91dd\u5c0d\u9019\u4e00\u8907\u96dc\u75be\u75c5\u7684\u4e2d\u6a1e\u548c\u5468\u908a\u6a5f\u5236\u3002<\/p>\n

\n

Informations et sources<\/h2>\n

R\u00e9f\u00e9rence scientifique<\/h3>\n

DOI\u00a0:<\/strong> https:\/\/doi.org\/10.1007\/s00210-026-05516-1<\/a><\/p>\n

Titre\u00a0:<\/strong> Bile acids in Alzheimer\u2019s disease: a double-edged sword in gut\u2013liver\u2013brain signaling and neurodegeneration<\/p>\n

Revue : <\/strong> Naunyn-Schmiedeberg’s Archives of Pharmacology<\/p>\n

\u00c9diteur : <\/strong> Springer Science and Business Media LLC<\/p>\n

Auteurs : <\/strong> Rehana Basri; Hayder M. Al-kuraishy; Mubarak Alruwaili; Ali I. Al-Gareeb; Ali K. Albuhadily; Athanasios Alexiou; Marios Papadakis; Safaa A. Faheem; Gaber El-Saber Batiha<\/p>\n","protected":false},"excerpt":{"rendered":"

\u81bd\u6c41\u9178\u5728\u963f\u723e\u8328\u6d77\u9ed8\u75c5\u4e2d\u626e\u6f14\u95dc\u9375\u89d2\u8272 \u81bd\u6c41\u9178\u9577\u671f\u4ee5\u4f86\u56e0\u5176\u5728\u8102\u80aa\u6d88\u5316\u548c\u809d\u81df\u4ee3\u8b1d\u4e2d\u7684\u4f5c\u7528\u800c\u70ba\u4eba\u6240\u77e5\uff0c\u4f46\u5b83\u5011\u4e5f\u5f71\u97ff\u8457\u4e2d… \u95b1\u8b80\u5168\u6587 \u81bd\u6c41\u9178\u5728\u963f\u723e\u8328\u6d77\u9ed8\u75c5\u4e2d\u626e\u6f14\u95dc\u9375\u89d2\u8272<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9,5,8],"tags":[],"class_list":["post-45","post","type-post","status-publish","format-standard","hentry","category-9","category-5","category-8","entry"],"_links":{"self":[{"href":"https:\/\/internationalsciencereview.com\/zh-tw\/wp-json\/wp\/v2\/posts\/45","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/internationalsciencereview.com\/zh-tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/internationalsciencereview.com\/zh-tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/internationalsciencereview.com\/zh-tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/internationalsciencereview.com\/zh-tw\/wp-json\/wp\/v2\/comments?post=45"}],"version-history":[{"count":1,"href":"https:\/\/internationalsciencereview.com\/zh-tw\/wp-json\/wp\/v2\/posts\/45\/revisions"}],"predecessor-version":[{"id":46,"href":"https:\/\/internationalsciencereview.com\/zh-tw\/wp-json\/wp\/v2\/posts\/45\/revisions\/46"}],"wp:attachment":[{"href":"https:\/\/internationalsciencereview.com\/zh-tw\/wp-json\/wp\/v2\/media?parent=45"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/internationalsciencereview.com\/zh-tw\/wp-json\/wp\/v2\/categories?post=45"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/internationalsciencereview.com\/zh-tw\/wp-json\/wp\/v2\/tags?post=45"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}