{"id":26,"date":"2026-06-11T12:30:15","date_gmt":"2026-06-11T10:30:15","guid":{"rendered":"https:\/\/internationalsciencereview.com\/vi\/2026\/06\/11\/mot-phuong-phap-dieu-tri-moi-giam-hieu-qua-mo-gan-va-can-nang-o-nguoi-beo-phi\/"},"modified":"2026-06-11T12:30:53","modified_gmt":"2026-06-11T10:30:53","slug":"mot-phuong-phap-dieu-tri-moi-giam-hieu-qua-mo-gan-va-can-nang-o-nguoi-beo-phi","status":"publish","type":"post","link":"https:\/\/internationalsciencereview.com\/vi\/2026\/06\/11\/mot-phuong-phap-dieu-tri-moi-giam-hieu-qua-mo-gan-va-can-nang-o-nguoi-beo-phi\/","title":{"rendered":"M\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi gi\u1ea3m hi\u1ec7u qu\u1ea3 m\u1ee1 gan v\u00e0 c\u00e2n n\u1eb7ng \u1edf ng\u01b0\u1eddi b\u00e9o ph\u00ec"},"content":{"rendered":"

“`html<\/p>\n

M\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi gi\u1ea3m hi\u1ec7u qu\u1ea3 m\u1ee1 gan v\u00e0 c\u00e2n n\u1eb7ng \u1edf ng\u01b0\u1eddi b\u00e9o ph\u00ec<\/h1>\n

M\u1ed9t lo\u1ea1i thu\u1ed1c \u0111\u1ed5i m\u1edbi, survodutide, th\u1ec3 hi\u1ec7n hi\u1ec7u qu\u1ea3 \u0111\u00e1ng k\u1ec3 trong vi\u1ec7c \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec v\u00e0 b\u1ec7nh gan li\u00ean quan \u0111\u1ebfn r\u1ed1i lo\u1ea1n chuy\u1ec3n h\u00f3a. T\u00ecnh tr\u1ea1ng n\u00e0y, \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 gan nhi\u1ec5m m\u1ee1 chuy\u1ec3n h\u00f3a, \u0111\u1eb7c tr\u01b0ng b\u1edfi s\u1ef1 t\u00edch t\u1ee5 b\u1ea5t th\u01b0\u1eddng c\u1ee7a m\u1ee1 trong gan, th\u01b0\u1eddng \u0111i k\u00e8m v\u1edbi vi\u00eam ho\u1eb7c x\u01a1 h\u00f3a. N\u00f3 \u1ea3nh h\u01b0\u1edfng \u0111\u1eb7c bi\u1ec7t \u0111\u1ebfn nh\u1eefng ng\u01b0\u1eddi th\u1eeba c\u00e2n v\u00e0 c\u00f3 th\u1ec3 ti\u1ebfn tri\u1ec3n th\u00e0nh c\u00e1c bi\u1ebfn ch\u1ee9ng nghi\u00eam tr\u1ecdng n\u1ebfu kh\u00f4ng \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb k\u1ecbp th\u1eddi.<\/p>\n

Nghi\u00ean c\u1ee9u \u0111\u00e3 bao g\u1ed3m 216 ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh m\u1eafc b\u1ec7nh b\u00e9o ph\u00ec, \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh b\u1edfi ch\u1ec9 s\u1ed1 kh\u1ed1i c\u01a1 th\u1ec3 (BMI) cao, v\u00e0 c\u00f3 gan nhi\u1ec5m m\u1ee1 nguy c\u01a1. Nh\u1eefng ng\u01b0\u1eddi tham gia \u0111\u01b0\u1ee3c ti\u00eam survodutide li\u1ec1u 6 mg m\u1ed7i tu\u1ea7n ho\u1eb7c gi\u1ea3 d\u01b0\u1ee3c. Sau 48 tu\u1ea7n, k\u1ebft qu\u1ea3 cho th\u1ea5y 84% nh\u1eefng ng\u01b0\u1eddi \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng survodutide \u0111\u00e3 gi\u1ea3m \u00edt nh\u1ea5t 30% m\u1ee1 gan, \u0111\u01b0\u1ee3c \u0111o b\u1eb1ng ch\u1ee5p c\u1ed9ng h\u01b0\u1edfng t\u1eeb. Trong khi \u0111\u00f3, ch\u1ec9 c\u00f3 24% nh\u1eefng ng\u01b0\u1eddi d\u00f9ng gi\u1ea3 d\u01b0\u1ee3c \u0111\u1ea1t \u0111\u01b0\u1ee3c ng\u01b0\u1ee1ng n\u00e0y. C\u00e2n n\u1eb7ng trung b\u00ecnh c\u0169ng gi\u1ea3m \u0111\u00e1ng k\u1ec3 h\u01a1n \u1edf nh\u00f3m \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb, v\u1edbi m\u1ee9c gi\u1ea3m 12,2% so v\u1edbi 1% \u1edf nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c.<\/p>\n

Survodutide ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch k\u00edch ho\u1ea1t \u0111\u1ed3ng th\u1eddi c\u00e1c th\u1ee5 th\u1ec3 glucagon v\u00e0 peptide-1 ki\u1ec3u glucagon, hai hormone tham gia v\u00e0o \u0111i\u1ec1u ch\u1ec9nh chuy\u1ec3n h\u00f3a v\u00e0 c\u1ea3m gi\u00e1c th\u00e8m \u0103n. T\u00e1c \u0111\u1ed9ng k\u00e9p n\u00e0y th\u00fac \u0111\u1ea9y gi\u1ea3m m\u1ee1 c\u01a1 th\u1ec3 v\u00e0 c\u1ea3i thi\u1ec7n s\u1ee9c kh\u1ecfe gan. C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 ph\u1ed5 bi\u1ebfn nh\u1ea5t, ch\u1ee7 y\u1ebfu l\u00e0 ti\u00eau h\u00f3a nh\u01b0 bu\u1ed3n n\u00f4n ho\u1eb7c ti\u00eau ch\u1ea3y, th\u01b0\u1eddng x\u1ea3y ra trong giai \u0111o\u1ea1n t\u0103ng li\u1ec1u d\u1ea7n d\u1ea7n v\u00e0 th\u01b0\u1eddng \u1edf m\u1ee9c nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh.<\/p>\n

Ngo\u00e0i vi\u1ec7c gi\u1ea3m m\u1ee1 gan v\u00e0 c\u00e2n n\u1eb7ng, ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb c\u00f2n mang l\u1ea1i nh\u1eefng c\u1ea3i thi\u1ec7n \u0111\u00e1ng k\u1ec3 \u0111\u1ed1i v\u1edbi nhi\u1ec1u ch\u1ec9 s\u1ed1 s\u1ee9c kh\u1ecfe. V\u00f2ng b\u1ee5ng trung b\u00ecnh gi\u1ea3m 11 cm, trong khi huy\u1ebft \u00e1p, n\u1ed3ng \u0111\u1ed9 \u0111\u01b0\u1eddng trong m\u00e1u v\u00e0 c\u00e1c ch\u1ec9 s\u1ed1 vi\u00eam \u0111\u1ec1u cho th\u1ea5y nh\u1eefng ti\u1ebfn tri\u1ec3n \u0111\u00e1ng k\u1ec3. Nh\u1eefng thay \u0111\u1ed5i n\u00e0y g\u1ee3i \u00fd m\u1ed9t l\u1ee3i \u00edch to\u00e0n di\u1ec7n \u0111\u1ed1i v\u1edbi s\u1ee9c kh\u1ecfe tim m\u1ea1ch chuy\u1ec3n h\u00f3a, t\u1eeb \u0111\u00f3 gi\u1ea3m thi\u1ec3u nguy c\u01a1 bi\u1ebfn ch\u1ee9ng li\u00ean quan \u0111\u1ebfn b\u00e9o ph\u00ec v\u00e0 b\u1ec7nh gan.<\/p>\n

K\u1ebft qu\u1ea3 c\u0169ng cho th\u1ea5y survodutide c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m vi\u00eam gan v\u00e0 l\u00e0m ch\u1eadm, th\u1eadm ch\u00ed \u0111\u1ea3o ng\u01b0\u1ee3c, ti\u1ebfn tr\u00ecnh x\u01a1 h\u00f3a, m\u1ed9t t\u00ecnh tr\u1ea1ng c\u1ee9ng h\u00f3a m\u00f4 gan c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn x\u01a1 gan. M\u1eb7c d\u00f9 nghi\u00ean c\u1ee9u ch\u1ec9 k\u00e9o d\u00e0i 48 tu\u1ea7n, nh\u1eefng c\u1ea3i thi\u1ec7n quan s\u00e1t \u0111\u01b0\u1ee3c cho th\u1ea5y ti\u1ec1m n\u0103ng \u0111i\u1ec1u tr\u1ecb quan tr\u1ecdng \u0111\u1ed1i v\u1edbi nh\u1eefng ng\u01b0\u1eddi m\u1eafc c\u00e1c b\u1ec7nh l\u00fd n\u00e0y, th\u01b0\u1eddng kh\u00f3 \u0111i\u1ec1u tr\u1ecb.<\/p>\n

Ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb n\u00e0y do \u0111\u00f3 m\u1edf ra m\u1ed9t tri\u1ec3n v\u1ecdng \u0111\u1ea7y h\u1ee9a h\u1eb9n cho b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh b\u00e9o ph\u00ec v\u00e0 gan nhi\u1ec5m m\u1ee1, b\u1eb1ng c\u00e1ch cung c\u1ea5p m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p hi\u1ec7u qu\u1ea3 \u0111\u1ec3 gi\u1ea3m c\u1ea3 m\u1ee1 c\u01a1 th\u1ec3 v\u00e0 c\u00e1c nguy c\u01a1 li\u00ean quan \u0111\u1ebfn b\u1ec7nh chuy\u1ec3n h\u00f3a.<\/p>\n

“`<\/p>\n

\n

Informations et sources<\/h2>\n

R\u00e9f\u00e9rence scientifique<\/h3>\n

DOI\u00a0:<\/strong> https:\/\/doi.org\/10.1038\/s41591-026-04479-3<\/a><\/p>\n

Titre\u00a0:<\/strong> Survodutide in adults with obesity and metabolic dysfunction-associated steatotic liver disease: SYNCHRONIZE-MASLD, a randomized, double-blind, placebo-controlled phase 3 trial<\/p>\n

Revue : <\/strong> Nature Medicine<\/p>\n

\u00c9diteur : <\/strong> Springer Science and Business Media LLC<\/p>\n

Auteurs : <\/strong> Lee M. Kaplan; Elena Startseva; Carel W. le Roux; Sean Wharton; Biykem Bozkurt; Daniel F. Mazo; Jessica von Schlippenbach; Sandra Gonz\u00e1lez Maldonado; Samina Ajaz Hussain; Guy W. Neff; Yaneicy Gonzalez Rojas; Charles Smith; Ramy Younes; Arun J. Sanyal; ; Antonio O. Martin; Mark Leibowitz; Douglas Denham; Kevin Korenblat; Michael Herman; Shekhar Challa; Rasha Youssef; Masi Khaja; Apinya Vutikullird; Humberto Aguilar; Naga Chalasani; James Maher; Ronald Surowitz; Cassandra Steimle; Yaneicy G. Rojas; Antonio Sanchez; Ruth E. Kavcioglu; Julio Vijil; Robert Perry; Guy Neff; Martha G. Navarro; Omer Khalid; Rizwana Mohseni; Julie Vu; Gregg Lucksinger; Satish Iduru; Dmitry Shuster; Bruce Segal; Paul Hellstern<\/p>\n","protected":false},"excerpt":{"rendered":"

“`html M\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi gi\u1ea3m hi\u1ec7u qu\u1ea3 m\u1ee1 gan v\u00e0 c\u00e2n n\u1eb7ng \u1edf ng\u01b0\u1eddi b\u00e9o ph\u00ec M\u1ed9t lo\u1ea1i thu\u1ed1c \u0111\u1ed5i m\u1edbi, survodutide, th\u1ec3 hi\u1ec7n hi\u1ec7u qu\u1ea3 \u0111\u00e1ng k\u1ec3 trong vi\u1ec7c \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec v\u00e0 b\u1ec7nh gan li\u00ean quan \u0111\u1ebfn r\u1ed1i lo\u1ea1n chuy\u1ec3n h\u00f3a. T\u00ecnh tr\u1ea1ng n\u00e0y, \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 gan nhi\u1ec5m… Continue reading M\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi gi\u1ea3m hi\u1ec7u qu\u1ea3 m\u1ee1 gan v\u00e0 c\u00e2n n\u1eb7ng \u1edf ng\u01b0\u1eddi b\u00e9o ph\u00ec<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,4],"tags":[],"class_list":["post-26","post","type-post","status-publish","format-standard","hentry","category-quoc-te","category-suc-khoe","entry"],"_links":{"self":[{"href":"https:\/\/internationalsciencereview.com\/vi\/wp-json\/wp\/v2\/posts\/26","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/internationalsciencereview.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/internationalsciencereview.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/internationalsciencereview.com\/vi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/internationalsciencereview.com\/vi\/wp-json\/wp\/v2\/comments?post=26"}],"version-history":[{"count":1,"href":"https:\/\/internationalsciencereview.com\/vi\/wp-json\/wp\/v2\/posts\/26\/revisions"}],"predecessor-version":[{"id":27,"href":"https:\/\/internationalsciencereview.com\/vi\/wp-json\/wp\/v2\/posts\/26\/revisions\/27"}],"wp:attachment":[{"href":"https:\/\/internationalsciencereview.com\/vi\/wp-json\/wp\/v2\/media?parent=26"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/internationalsciencereview.com\/vi\/wp-json\/wp\/v2\/categories?post=26"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/internationalsciencereview.com\/vi\/wp-json\/wp\/v2\/tags?post=26"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}